N,N-Dimethylglycine

• Catalog No.: A19670
• CAS Number: 1118-68-9
• M. F.: C4H9NO2
• M. W.: 103.11976
• Purity: 98+%

SYNONYMS

• Title: N,N-二甲基甘氨酸
• IUPAC name: 2-(dimethylamino)acetic acid
• IUPAC Traditional name: dimethylglycine
• Synonyms: Dimethylaminoacetic acid

DATABASE IDS

• EC Number: 214-267-8
• Merck Index: 143244
• MDL Number: MFCD00004283
• CAS Number: 1118-68-9

PROPERTIES

• Purity: 98+%
• Melting Point: 179-183°C
• GHS Hazard statements: H302
• GHS Precautionary statements: P264-P270-P301+P312-P330-P501A
• RTECS: MB9865000
• Storage Warning: Hygroscopic
• TSCA Listed: 是

REFERENCES

• Additive which promotes the Heck coupling reaction of unactivated aryl chlorides with alkenes, catalyzed by Pd(II) in the presence of Tetraphenylphosphonium chloride, A10575: Angew. Chem. Int. Ed., 37, 481 (1998). The combination with Bis(benzonitrile)dichloropalladum constitutes a highly active phosphine-free catalyst system for Heck reactions of aryl bromides: Tetrahedron Lett., 39, 8449 (1998); see also: Tetrahedron Lett., 39, 8449 (1998). Promotes the copper(I)-catalyzed Ullmann-type coupling of aryl bromides and iodides with amines: Org. Lett., 5, 2453 (2003), and phenols: Org. Lett., 5, 3799 (2003), to give substituted anilines and diaryl ethers, respectively. Aryl iodides can also be coupled with aliphatic alcohols to give aryl alkyl ethers: Synlett, 243 (2007). In combinatiion with CuI, vinyl halides with phenols give aryl vinyl ethers: Synlett, 1767 (2005).