2,2,6,6-Tetramethylpiperidine

• Catalog No.: A18712
• CAS Number: 768-66-1
• M. F.: C9H19N
• M. W.: 141.25386
• Purity: 98+%

SYNONYMS

• Title: 2,2,6,6-四甲基哌啶
• IUPAC name: 2,2,6,6-tetramethylpiperidine
• IUPAC Traditional name: 2,2,6,6-tetramethylpiperidine

DATABASE IDS

• CAS Number: 768-66-1
• EC Number: 212-199-3
• MDL Number: MFCD00005985
• Beilstein Number: 103296

PROPERTIES

• Purity: 98+%
• Boiling Point: 152-154°C
• Density: 0.832
• Flash Point: 34°C(93°F)
• Melting Point: -59°C
• Refractive Index: 1.4440
• GHS Hazard statements: H314-H318-H226-H302
• European Hazard Symbols: X
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P280-P305+P351+P338-P309-P310
• Risk Statements: 10-22-34
• RTECS: TN4220000
• Safety Statements: 26-36/37/39-45
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN2733
• Packing Group: III

REFERENCES

• Lithiation gives a highly-hindered, non-nucleophilic strong base; see, e.g. Org. Synth. Coll., 6, 571 (1988);9, 426 (1998); Tetrahedron, 50, 3099 (1994). For use in selective isomerization of epoxides to aldehydes, see: J. Chem. Soc., Chem. Commun., 2103 (1994). For a study of the influence of TMEDA and related chelating ligands on the solution structure of the lithiated base, see: J. Org. Chem., 62, 5748 (1997). The Mg derivative, obtained by reaction with n-BuMgCl, is also an effective strong base which has been used in the regioselective ortho-metallation of pyridine carbamates and carboxamides: J. Org. Chem., 60,8414 (1995).