2,2,2-Tribromoethanol

• Catalog No.: A18706
• CAS Number: 75-80-9
• M. F.: C2H3Br3O
• M. W.: 282.75662
• Purity: 99%

SYNONYMS

• Title: 2,2,2-三溴乙醇
• IUPAC name: 2,2,2-tribromoethan-1-ol
• IUPAC Traditional name: ethanol, 2,2,2-tribromo-
• Synonyms: 2,2,2-Tribromoethyl alcohol

DATABASE IDS

• EC Number: 200-903-1
• CAS Number: 75-80-9
• MDL Number: MFCD00004671
• Beilstein Number: 1733249

PROPERTIES

• Purity: 99%
• Boiling Point: 92-93°C/10mm
• Melting Point: 77-80°C
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: X
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 22-36/37/38
• RTECS: KM3675000
• Safety Statements: 26-36/37
• Storage Warning: Light Sensitive
• TSCA Listed: 是

REFERENCES

• Carboxyl groups can be protected as tribromoethyl esters, e.g. by reaction of the acid chloride in the presence of N,N-dimethylaniline. The group is readily cleaved with Zn/AcOH: J. Chem. Soc., Pekin 1., 2875 (1993); (cf. 2,2,2-Trichloroethanol, L08163). The group has also been exploited in the activation of carboxylic acids for amidation with amines, by reductive cleavage of the tribromoethyl ester with a P(III) reagent, preferably Hexamethylphosphorous triamide, A12571, and triethylamine. In an analogous esterification method with alcohols, tributylphosphine - DMAP was the preferred system: J. Org. Chem., 64, 1430 (1999).