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2,2,2-Tribromoethanol_Molecular_structure_CAS_75-80-9)
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2,2,2-Tribromoethanol

Catalog No. A18706 Name Alfa Aesar
CAS Number 75-80-9 Website
M. F. C2H3Br3O Telephone
M. W. 282.75662 Fax
Purity 99% Email
Storage Chembase ID: 78451

SYNONYMS

Title
2,2,2-三溴乙醇
IUPAC name
2,2,2-tribromoethan-1-ol
IUPAC Traditional name
ethanol, 2,2,2-tribromo-
Synonyms
2,2,2-Tribromoethyl alcohol

DATABASE IDS

EC Number 200-903-1
CAS Number 75-80-9
MDL Number MFCD00004671
Beilstein Number 1733249

PROPERTIES

Purity 99%
Boiling Point 92-93°C/10mm
Melting Point 77-80°C
GHS Pictograms GHS07
GHS Hazard statements H302-H315-H319-H335
European Hazard Symbols X
GHS Precautionary statements P261-P305+P351+P338-P302+P352-P321-P405-P501A
Risk Statements 22-36/37/38
RTECS KM3675000
Safety Statements 26-36/37
Storage Warning Light Sensitive
TSCA Listed

DETAILS

REFERENCES

  • Carboxyl groups can be protected as tribromoethyl esters, e.g. by reaction of the acid chloride in the presence of N,N-dimethylaniline. The group is readily cleaved with Zn/AcOH: J. Chem. Soc., Pekin 1., 2875 (1993); (cf. 2,2,2-Trichloroethanol, L08163). The group has also been exploited in the activation of carboxylic acids for amidation with amines, by reductive cleavage of the tribromoethyl ester with a P(III) reagent, preferably Hexamethylphosphorous triamide, A12571, and triethylamine. In an analogous esterification method with alcohols, tributylphosphine - DMAP was the preferred system: J. Org. Chem., 64, 1430 (1999).