2-(p-Toluenesulfonyl)ethanol

• Catalog No.: A18249
• CAS Number: 22381-54-0
• M. F.: C9H12O3S
• M. W.: 200.25478
• Purity: 98%

SYNONYMS

• Title: 2-(对甲苯磺酰)乙醇
• IUPAC name: 2-(4-methylbenzenesulfonyl)ethan-1-ol
• IUPAC Traditional name: 2-(4-methylbenzenesulfonyl)ethanol
• Synonyms: 2-(p-Tosyl)ethanol; 2-(4-Methylphenylsulfonyl)ethanol

DATABASE IDS

• EC Number: 000-000-0
• Beilstein Number: 1961132
• CAS Number: 22381-54-0
• MDL Number: MFCD00041757

PROPERTIES

• Purity: 98%
• Boiling Point: 178-181°C/0.2mm
• Melting Point: 50-53°C
• TSCA Listed: 是

REFERENCES

• Reagent for protection of the carboxyl group as its 2-(p-toluenesulfonyl)ethyl (Tse) [2-(4-methylphenylsulfonyl)ethyl (Mpse)] ester, e.g. by DCC coupling. The Tse group is useful for carboxyl protection of Boc amino acids in peptide synthesis, since it is stable to the acidic conditions used for Boc cleavage, but readily cleaved by mild base, e.g. dilute NaOH or Na₂CO₃ in dioxan-water: J. Chem. Soc.(C)., 2612 (1968). It can also be cleaved by non-aqueous bases, e.g. DBN: J. Chem. Soc., Chem. Commun., 1031 (1972), DBU: Tetrahedron Lett., 25, 2163 (1984), or TBAF in THF: Chem. Lett., 1595 (1987).