Lithium aluminum hydride, powder

• Catalog No.: A18116
• CAS Number: 16853-85-3
• M. F.: AlLi
• M. W.: 33.922538
• Purity: 97%

SYNONYMS

• Title: 氢化铝锂, powder
• IUPAC name: lithium(1+) ion alumanuide
• IUPAC Traditional name: lithium(1+) ion alumanuide
• Synonyms: Lithium aluminum hydride; Lithium tetrahydridoaluminate

DATABASE IDS

• MDL Number: MFCD00011075
• Merck Index: 14349
• EC Number: 240-877-9
• CAS Number: 16853-85-3

PROPERTIES

• Purity: 97%
• Density: 0.917
• Melting Point: >125°C dec.
• GHS Hazard statements: H260-H301-H314-H318
• European Hazard Symbols: Corrosive (C)
• European Hazard Symbols: Flammable (F)
• GHS Precautionary statements: P231+P232-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 15-35
• RTECS: BD0100000
• Safety Statements: 7/8-26-36/37/39-43-45
• Storage Warning: Air & Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 4.3
• UN Number: UN1410
• Packing Group: I

REFERENCES

• Mixing with a flammable solvent must always be carried out under an inert atmosphere.
• Reverse addition (solvent to reagent), if done rapidly, may be safer.
• For THF, at least 10ml solvent per gram of reagent is recommended to absorb heat of mixing.
• Efficient stirring is essential during mixing, reaction and workup.
• The use of water or steam baths, or of electric heating mantles is to be strongly discouraged.
• Many procedures for reactions with this reagent which have been described in the literature are potentially unsafe on anything other than a very small scale, since often no precautions are given for mixing the reagent with flammable solvents. The following suggestions are offered for laboratory scale reductions:
• For phase-transfer reductions in hydrocarbon solvents, see 15-Crown-5, A12265. For formation of lithium tris(diethylamino)aluminum hydride and use in the reduction of esters or amides to aldehydes, see Diethylamine, A11716. For formation of a reagent for reduction of carboxylic acids to aldehydes, see 1-Methylpiperazine, A10837.
• For reduction of sulfones, see Titanium(IV) chloride, 14713.
• Monograph: J. Seyden-Penne, Reductions by the Alumino- and Borohydrides In Organic Synthesis, 2nd ed., Wiley, N.Y. (1997).
• The reduction reaction should preferably be controlled by adjusting the rate of addition of the substrate rather than relying on external heating or cooling.
• External heating or cooling, if required, should be by means of a suitable inert oil.
• The use of Diethoxymethane, B23134 as a reaction solvent has also been recommended.