2-Amino-2-methyl-1-propanol

• Catalog No.: A17814
• CAS Number: 124-68-5
• M. F.: C4H11NO
• M. W.: 89.13624
• Purity: 95%, may cont. ca 5% water

SYNONYMS

• Title: 2-氨基-2-甲基-1-丙醇
• IUPAC name: 2-amino-2-methylpropan-1-ol
• IUPAC Traditional name: 2-amino-2-methyl-1-propanol
• Synonyms: Isobutanolamine; AMP

DATABASE IDS

• MDL Number: MFCD00008051
• EC Number: 204-709-8
• Merck Index: 14449
• CAS Number: 124-68-5
• Beilstein Number: 505979

PROPERTIES

• Purity: 95%, may cont. ca 5% water
• Boiling Point: 164-166°C
• Density: 0.934
• Flash Point: 67°C(152°F)
• Melting Point: 24-28°C
• Refractive Index: 1.4455
• GHS Hazard statements: H315-H319-H227-H402-H412
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P280G-P273-P305+P351+P338-P337+P313
• Risk Statements: 36/38-52/53
• RTECS: UA5950000
• Safety Statements: 61
• TSCA Listed: 是

REFERENCES

• 2-Aryl-4,4-dimethyl-2-oxazolines are activated towards ortho-lithiation: J. Org. Chem., 40, 3058 (1975). Methoxy- or fluoro-substituents in the ortho-position are readily substitutied by organolithiums or Grignards, providing a versatile route to biaryls: J. Am. Chem. Soc ., 97, 7383 (1975). For examples, see: Org. Synth. Coll., 9, 258 (1998). The oxazoline can also be converted to an aldehyde by methylation and borohydride reduction.
  
• Buffer and phosphate acceptor in assay of phosphatases: Methods of Enzymatic Analysis, 3rd ed., H. U. Bergmeyer, Ed., Verlag Chemie, Weinheim (1984), vol. 4, p76.
• For reviews of the use of oxazolines in synthesis, see: Angew. Chem. Int. Ed., 15, 270 (1976); Tetrahedron, 41, 837 (1985); 50, 2297 (1994).
• Precursor of 2-substituted-4,4-dimethyl-2-oxazoline derivatives of carboxylic acids: J. Org. Chem., 39, 2787 (1974), developed by Meyers. The oxazoline, which is readily formed with the acid chloride and thionyl chloride, is stable to base, organometallic reagents, etc., but readily cleaved by dilute acid. For further information on the reactivity of these derivatives, see 2,4,4-Trimethyl-2-oxazoline, L00181.