N,O-Dimethylhydroxylamine hydrochloride

• Catalog No.: A17469
• CAS Number: 6638-79-5
• M. F.: C2H8ClNO
• M. W.: 97.54402
• Purity: 98%

SYNONYMS

• Title: N,O-二甲基羟胺盐酸盐
• IUPAC name: methoxy(methyl)amine hydrochloride
• IUPAC Traditional name: N,O-dimethylhydroxylamine hydrochloride

DATABASE IDS

• MDL Number: MFCD00012485
• Beilstein Number: 3650353
• CAS Number: 6638-79-5
• EC Number: 229-642-1

PROPERTIES

• Purity: 98%
• Melting Point: 112-115°C
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• Safety Statements: 26-37
• Storage Warning: Hygroscopic
• TSCA Listed: 是

REFERENCES

• The N-methoxy-N-methylamides (Weinreb amides) of carboxylic acids, N-protected amino acids and peptides are readily prepared from the acid chloride or mixed anhydride, or from the acid in the presence of 2-Chloro-1-methylpyridinium iodide, A12820: Synth. Commun., 25, 1277 (1995); or BOP Reagent (1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, A16140): J. Org. Chem., 61, 4999 (1996). The products undergo a number of useful transformations, e.g.:
• Reaction with Grignard or organolithium reagents gives ketones: Tetrahedron Lett., 22, 3815 (1981). Reduction with Lithium aluminum hydride, A18116, gives the aldehyde: Synthesis, 676 (1983). For subsequent conversion of Boc-amino acid derived aldehydes and ketones to pyrrole derivatives, see: J. Org. Chem., 61, 4999 (1996). Coupling with alkyl acetoacetates gives ? δ -diketo esters: Tetrahedron Lett., 29, 6467 (1988). For conversion to ɑ -diketones or ɑ -keto esters, see: J. Org. Chem., 54, 3913 (1989).