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1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate_Molecular_structure_CAS_56602-33-6)
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1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate

Catalog No. A16140 Name Alfa Aesar
CAS Number 56602-33-6 Website
M. F. C12H22F6N6OP2 Telephone
M. W. 442.2806212 Fax
Purity 98% Email
Storage Chembase ID: 94885

SYNONYMS

Title
1H-苯并三唑-1-基氧代三(二甲氨基)磷鎓 六氟磷酸盐
IUPAC name
(1H-1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphanium; hexafluoro-λ5-phosphanuide
IUPAC Traditional name
(1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphanium hexafluorophosphate
Synonyms
BOP Reagent
Castro's reagent

DATABASE IDS

CAS Number 56602-33-6
MDL Number MFCD00011948
Beilstein Number 4287025
EC Number 260-279-1

PROPERTIES

Purity 98%
Melting Point ca 138°C dec.
GHS Pictograms GHS02
GHS Pictograms GHS07
GHS Hazard statements H228-H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
European Hazard Symbols Flammable Flammable (F)
GHS Precautionary statements P210-P241-P305+P351+P338-P302+P352-P405-P501A
Risk Statements 11-36/37/38-44
Safety Statements 26-37-60
Storage Warning Moisture & Light Sensitive
TSCA Listed
Hazard Class 4.1
UN Number UN1325
Packing Group II

DETAILS

REFERENCES

  • Reagent for high yield, low racemization peptide coupling: Tetrahedron Lett., 1219 (1975). See Appendix 6.
  • Mild and efficient reagent for the preparation of esters from carboxylic acids and alcohols: Tetrahedron Lett., 36, 4253 (1995); for esterification of amino acids at low temperatures, see: Tetrahedron Lett., 35, 5603 (1994); for use in formation of mixed phosphonate diesters, see: J. Org. Chem., 60, 5214 (1995).
  • The carboxyphosphonium salts formed by reaction with carboxylic acids can be reduced with NaBH4, providng a mild method for reduction of acids to alcohols: Tetrahedron lett., 39, 3319 (1998).
  • Promotes the reaction of aliphatic primary amines with CS2 to give isothiocyanates which can be isolated in high yield or reacted in situ with nucleophiles: J. Chem. Soc., Chem. Commun., 1995 (1995).