Methyltriphenylphosphonium bromide

• Catalog No.: A15878
• CAS Number: 1779-49-3
• M. F.: C19H18BrP
• M. W.: 357.223981
• Purity: 98+%

SYNONYMS

• Title: 甲基三苯基溴化磷鎓
• IUPAC name: methyltriphenylphosphanium bromide
• IUPAC Traditional name: methyltriphenylphosphanium bromide

DATABASE IDS

• Beilstein Number: 3599467
• MDL Number: MFCD00011804
• EC Number: 217-218-9
• CAS Number: 1779-49-3

PROPERTIES

• Purity: 98+%
• Melting Point: 231-234°C
• GHS Hazard statements: H302-H315-H319-H335-H411-H401
• European Hazard Symbols: X
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 22-36/37/38-51/53
• Safety Statements: 26-36/37-57
• Storage Warning: Hygroscopic
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN2811
• Packing Group: III

REFERENCES

• Precursor of Wittig ylide for methylenation of carbonyl compounds (see Appendix 1). See, e.g.: Org. Synth. Coll., 5, 751 (1973). A simplified procedure using K₂CO₃ in triglyme has been reported: Synth. Commun., 22, 513 (1992).
• Where the ylide is insufficiently reactive, a further proton can be removed by s-BuLi or t-BuLi, and the resulting lithio ylide reacted with hindered ketones such as fenchone: J. Am. Chem. Soc., 104, 4724 (1982). Reaction of the lithio ylide with an epoxide generates a new ylide, with which Wittig olefination of aldehydes gives trans-homoallylic alcohols (same ref.):