Chloroacetyl chloride

• Catalog No.: A15846
• CAS Number: 79-04-9
• M. F.: C2H2Cl2O
• M. W.: 112.94268
• Purity: 98%

SYNONYMS

• Title: 氯乙酰氯
• IUPAC name: 2-chloroacetyl chloride
• IUPAC Traditional name: chloroacetyl chloride

DATABASE IDS

• CAS Number: 79-04-9
• Merck Index: 142067
• Beilstein Number: 605439
• EC Number: 201-171-6
• MDL Number: MFCD00000725

PROPERTIES

• Purity: 98%
• Boiling Point: 105-106°C
• Density: 1.417
• Melting Point: -22°C
• Refractive Index: 1.4530
• GHS Hazard statements: H301-H311-H331-H372-H314-H400
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A
• Risk Statements: 14-23/24/25-35-48/23-50
• RTECS: AO6475000
• Safety Statements: 7/8-9-26-36/37/39-45-61
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN1752
• Packing Group: I

REFERENCES

• Reagent for the protection of amines as their chloroacetamides. The protecting group can be removed by reaction with thiourea derivatives, forming 2-thiazolidin-4-ones as by-products: J. Am. Chem. Soc., 90, 4508 (1968); Gazz. Chim. Ital., 98, 1261 (1968). Side reactions can be minimized by using 1-Piperidinethiocarboxamide, L12445, as the thiourea: Angew. Chem. Int. Ed., 10, 75 (1971).
• Also used for the protection of alcohols as their chloroacetates: Tetrahedron Lett., 251 (1979). They are hydrolyzed very readily in the presence of many other ester functions: J. Am. Chem. Soc., 86, 118 (194); J. Chem. Soc., Perkin 1, 934 (1975); or can be cleaved with thiourea: Tetrahedron Lett., 251 (1979), ethylenediamine, or mercaptoethylamine: J. Org. Chem., 35, 1940 (1970).