Progabide

• Catalog No.: DB00837
• CAS Number: 62666-20-0
• M. F.: C17H16ClFN2O2
• M. W.: 334.7725432

SYNONYMS

• IUPAC name: 4-{[(4-chlorophenyl)[(1E)-3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene]methyl]amino}butanamide
• IUPAC Traditional name: gabren
• Brand Name: Gabrene; Gabren
• Synonyms: Halogabide; Progabide [Usan:Ban:Inn]; Progabidum [INN-Latin]; Progabida [INN-Spanish]

DATABASE IDS

• PubChem CID: 5361323
• CAS Number: 62666-20-0
• PubChem SID: 46506568

PROPERTIES

• Hydrophobicity(logP): 2.6
• Solubility: 70.9 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: Progabide is an analog and prodrug of gamma-aminobutyric acid. It is commonly used in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors. Progabide has been investigated for many diseases besides epilepsy, including Parkinson's disease, schizophrenia, clinical depression and anxiety disorder with varying success.
• Indication: Indicated for the treatment of epilepsy.
• Pharmacology: Progabide, a fatty acid derivative, is a GABA receptor agonist used to treat the symptoms of epilepsy.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic
• Absorption: Well absorbed with a bioavailability of 60%
• Half Life: 4 hours
• Protein Binding: 95%
• References: Bartholini G, Scatton B, Zivkovic B, Lloyd KG: GABA receptor agonists and extrapyramidal motor function: therapeutic implications for Parkinson's disease. Adv Neurol. 1987;45:79-83. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Bartholini G, Scatton B, Zivkovic B, Lloyd KG: GABA receptor agonists and extrapyramidal motor function: therapeutic implications for Parkinson's disease. Adv Neurol. 1987;45:79-83. Pubmed