4-Nitrobenzyl alcohol

• Catalog No.: A15742
• CAS Number: 619-73-8
• M. F.: C7H7NO3
• M. W.: 153.13538
• Purity: 99%

SYNONYMS

• Title: 4-硝基苄醇
• IUPAC name: (4-nitrophenyl)methanol
• IUPAC Traditional name: 4-nitrobenzyl alcohol

DATABASE IDS

• CAS Number: 619-73-8
• Beilstein Number: 1424026
• EC Number: 210-611-6
• MDL Number: MFCD00007376

PROPERTIES

• Purity: 99%
• Boiling Point: 185°C/12mm
• Flash Point: 180°C(356°F)
• Melting Point: 92-95°C
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• RTECS: DP0657100
• Safety Statements: 26-37
• TSCA Listed: 是

REFERENCES

• Protection of alcohols as their 4-nitrobenzyl ethers has been carried out, e.g. in the presence of trifluoroacetic anhydride and 2,6-lutidine: Tetrahedron Lett., 31, 389 (1990).
• Selective deprotection at room temperature can be accomplished by sodium dithionite in aqueous acetonitrile: Synth. Commun., 12, 219 (1982). Photolytic cleavage has been employed in the carbohydrate series: J. Org. Chem., 37, 2281, 2285 (1972). For reviews of photoremovable protecting groups, see: Synthesis, 1 (1980); Org. Photochem., 9, 225 (1987). Reduction to the aniline, followed by chemical or electrolytic oxidation has also been reported: Tetrahedron Lett., 31, 389 (1990).
• Has also found use to protect carboxylic acids as their 4-nitrobenzyl esters, particularly in the penicillin and peptide fields. See also 4-Nitrobenzyl bromide, A15236, and 4-Nitrobenzyl chloride, A15749.