Pentafluorophenol

• Catalog No.: A15574
• CAS Number: 771-61-9
• M. F.: C6HF5O
• M. W.: 184.063556
• Purity: 99%

SYNONYMS

• Title: 五氟苯酚
• IUPAC name: pentafluorophenol
• IUPAC Traditional name: pentafluorophenol
• Synonyms: PFP

DATABASE IDS

• CAS Number: 771-61-9
• MDL Number: MFCD00002156
• Beilstein Number: 1912584
• EC Number: 212-235-8

PROPERTIES

• Purity: 99%
• Boiling Point: 143°C
• Density: 1.757
• Flash Point: 72°C(161°F)
• Melting Point: 32-36°C
• Refractive Index: 1.4270
• GHS Hazard statements: H301-H311-H314-H318
• European Hazard Symbols: X
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A
• Risk Statements: 21/22-34
• RTECS: SM6680000
• Safety Statements: 26-36/37/39-45
• TSCA Listed: 是
• Hazard Class: 8
• UN Number: UN3261
• Packing Group: II

REFERENCES

• Widely used for peptide coupling (see Appendix 6) via the active PFP esters, generally prepared by carbodiimide coupling: Liebigs Ann. Chem., 1421 (1973); Tetrahedron Lett., 1785 (1974). With Fmoc-protected amino acids, the coupling takes place very rapidly, which reduces the amount of Fmoc-cleavage during the peptide bond formation: Synthesis, 325 (1983). Fmoc protected PFP esters have also been applied in solid phase peptide synthesis: Tetrahedron, 44, 843 (1988). PFP esters have been recommended for preparation of derivatives of heterocyclic acids, effective where DCC or DIC alone fail: Synth. Commun., 28, 753 (1998).
• For preparation and use of the moderately stable PFP formate as a formylating agent for amines and amino acids, see: Synthesis, 510 (1987).