Ethyl chloroacetate

• Catalog No.: A15554
• CAS Number: 105-39-5
• M. F.: C4H7ClO2
• M. W.: 122.55018
• Purity: 99%

SYNONYMS

• Title: 氯代乙酸乙酯
• IUPAC name: ethyl 2-chloroacetate
• IUPAC Traditional name: ethyl chloroacetate
• Synonyms: Chloroacetic acid ethyl ester

DATABASE IDS

• Merck Index: 143783
• MDL Number: MFCD00000932
• CAS Number: 105-39-5
• EC Number: 203-294-0
• Beilstein Number: 506455

PROPERTIES

• Purity: 99%
• Boiling Point: 142-144°C
• Density: 1.159
• Flash Point: 54°C(149°F)
• Melting Point: -26°C
• Refractive Index: 1.4210
• GHS Hazard statements: H301-H311-H331-H226-H400
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P210-P301+P310-P303+P361+P353-P361-P405-P501A
• Risk Statements: 23/24/25-50
• RTECS: AF9110000
• Safety Statements: 1/2-7/9-45-61
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN1181
• Packing Group: II

REFERENCES

• For examples of use in the Darzens reaction with carbonyl compounds to give glycidic esters, see: Org. Synth. Coll., 3, 727 (1955); 4, 459 (1963); reviews: Org. React., 5, 413 (1949); Chem. Rev., 55, 283 (1955). In the presence of base, glycidic esters rearrange to ɑ-substituted aldehydes: Org. Synth. Coll., 3, 733 (1955):
  
• For a theoretical study of a proposed cyclic transition state in the Darzens reaction, see: J. Org. Chem., 61, 6723 (1996).
• Undergoes phase-transfer catalyzed carbene-like addition to activated alkenes to give cyclopropane derivatives: Synth. Commun., 22, 1651 (1992):
  
• Compare (±)-2-Chloropropionic acid, A12860, for a similar reaction.