2-Chloropyrimidine

• Catalog No.: A15394
• CAS Number: 1722-12-9
• M. F.: C4H3ClN2
• M. W.: 114.53302
• Purity: 98%

SYNONYMS

• Title: 2-氯嘧啶
• IUPAC name: 2-chloropyrimidine
• IUPAC Traditional name: pyrimidine, 2-chloro-

DATABASE IDS

• MDL Number: MFCD00006060
• EC Number: 217-020-2
• CAS Number: 1722-12-9
• Beilstein Number: 107171

PROPERTIES

• Purity: 98%
• Boiling Point: 75-76°C/10mm
• Flash Point: 98°C(208°F)
• Melting Point: 64-67°C
• GHS Hazard statements: H301-H319-H317-H335
• European Hazard Symbols: X
• GHS Precautionary statements: P280H-P262-P305+P351+P338-P309-P310
• Risk Statements: 22-36/37-43
• Safety Statements: 24-26-36/37
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否
• Hazard Class: 6.1
• UN Number: UN2811
• Packing Group: III

REFERENCES

• Alkoxylation with 3-butyn-1-ol, followed by intramolecular Diels-Alder reaction, leads to a fused pyridine system, by a sequence analogous to that shown for 2-Chloropyrazine, A10108: Tetrahedron, 45, 803 (1989). For a similar sequence using the anion of an alkynylmalononitrile, see: Tetrahedron, 45, 5151 (1989). For synthesis of a benzofuropyridine by the cyclization of a 2-(alkynylphenoxy)pyrimidine, see: Tetrahedron, 45, 6511 (1989).
• Organolithium reagents add to the 1,6-imine bond, giving, after aromatization with DDQ, 6-substituted 2-chloropyrimidines: J. Org. Chem., 53, 4137 (1988).