2-Chloroethanesulfonyl chloride

• Catalog No.: A15377
• CAS Number: 1622-32-8
• M. F.: C2H4Cl2O2S
• M. W.: 163.02296
• Purity: 98%

SYNONYMS

• Title: 2-氯乙烷磺酰氯
• IUPAC name: 2-chloroethane-1-sulfonyl chloride
• IUPAC Traditional name: 2-chloroethanesulfonyl chloride
• Synonyms: 2-Chloroethylsulfonyl chloride

DATABASE IDS

• EC Number: 216-594-1
• CAS Number: 1622-32-8
• MDL Number: MFCD00007461
• Beilstein Number: 1751202

PROPERTIES

• Purity: 98%
• Boiling Point: 203°C
• Density: 1.560
• Flash Point: >110°C(230°F)
• Refractive Index: 1.4915
• GHS Hazard statements: H301-H330-H314-H318
• European Hazard Symbols: Highly toxic (T+)
• GHS Precautionary statements: P260-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501A
• Risk Statements: 22-26-34
• RTECS: KI8060000
• Safety Statements: 9-23-26-28-36/37/39-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN3390
• Packing Group: I

REFERENCES

• In the presence of a base, converts alcohols to vinyl sulfonates: J. Am. Chem. Soc., 68, 1797 (1946); Angew. Chem. Int. Ed., 4, 300 (1965). These electrophilic alkenes readily undergo conjugate addition reactions with various nucleophiles:
  
• Reaction with pentafluorophenol, in the presence of Et₃N, gives PFP vinylsulfonate, which can be converted to a sulfonamide via tin-mediated radical addition of alkyl halides to the olefinic bond, followed by displacement of the PFP group with an amine: Org. Lett., 42549 (2002).