1,3-Propanedithiol

• Catalog No.: A15261
• CAS Number: 109-80-8
• M. F.: C3H8S2
• M. W.: 108.22562
• Purity: 97%

SYNONYMS

• Title: 1,3-丙二硫醇
• IUPAC name: propane-1,3-dithiol
• IUPAC Traditional name: 1,3-propanedithiol
• Synonyms: Trimethylene mercaptan

DATABASE IDS

• Beilstein Number: 1071197
• Merck Index: 147801
• MDL Number: MFCD00004904
• CAS Number: 109-80-8
• EC Number: 203-706-9

PROPERTIES

• GHS Hazard statements: H315-H319-H335-H227
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P210-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• RTECS: TZ2585500
• Safety Statements: 23-26-37-60
• TSCA Listed: 是
• Hazard Class: 9
• UN Number: UN3334
• Purity: 97%
• Boiling Point: 168-170°C
• Density: 1.077
• Flash Point: 63°C(145°F)
• Melting Point: -79°C
• Refractive Index: 1.5400
• Solubility: Slightly soluble in water. Miscible with alcohol, ether, chloroform, ether

REFERENCES

• Precursor of cyclic dithioacetal (1,3-dithiane) derivatives of carbonyl compounds. The protection step is catalyzed by Lewis acids, e.g. BF₃ etherate: Tetrahedron Lett., 871 (1971), TiCl₄: Tetrahedron Lett., 24, 1289 (1983), Aluminum trifluoromethanesulfonate, B20785, or Indium(III) trifluoromethanesulfonate, 40131. Diothioacetalization can be accomplished under neutral, solvent-free conditions using Lithium trifluoromethanesulfonate, 39322, as catalyst: Tetrahedron Lett., 40, 4055 (1999). For the preparation of monocyclic dithioacetals of ?-diketones at low temperature in the presence of BF₃ etherate, see: Tetrahedron, 44, 2283 (1988).
• For deprotection methods and uses of 1,3-dithianes as acyl anion equivalents, see: 1,3-Dithiane, A10505.
• Alternatively, 1,3-dithianes can be prepared by alkylation with reactive gem-dihalides under phase-transfer conditions: Liebigs Ann. Chem., 1589 (1982).