Dimethyl acetone-1,3-dicarboxylate

• Catalog No.: A14969
• CAS Number: 1830-54-2
• M. F.: C7H10O5
• M. W.: 174.1513
• Purity: 97%

SYNONYMS

• Title: 丙酮二羧酸二甲酯
• IUPAC name: 1,5-dimethyl 3-oxopentanedioate
• IUPAC Traditional name: 1,5-dimethyl 3-oxopentanedioate
• Synonyms: Dimethyl 3-oxoglutarate; Acetone-1,3-dicarboxylic acid dimethyl ester

DATABASE IDS

• MDL Number: MFCD00008462
• EC Number: 217-385-8
• Beilstein Number: 1366042
• CAS Number: 1830-54-2

PROPERTIES

• Purity: 97%
• Boiling Point: 237-241°C
• Density: 1.185
• Flash Point: >110°C(230°F)
• Melting Point: 16-17°C
• Refractive Index: 1.4440
• GHS Hazard statements: H317
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P280G-P262
• Risk Statements: 43
• Safety Statements: 24-37
• TSCA Listed: 是

REFERENCES

• Reacts with ɑ-diketones in aqueous buffer to give bicyclic diketones (Weiss-Cook condensation): Tetrahedron Lett., 4885 (1968); Org. Synth. Coll., 7, 50 (1990):
  
• See also: J. Chem. Soc., Perkin 1, 1425 (1997). Use of cyclic ɑ-diketones leads to propellanes: Can. J. Chem., 189 (1978).
• The Na salt (NaH/THF) reacts with alkynals: J. Org. Chem., 62, 5688 (1997), or ynones: Synth. Commun., 28, 1525 (1998), under mild conditions to give 4-substituted dimethyl 2-hydroxyisophthalates via a Michael addition - aldol cyclization process; see 3-Butyn-2-one, L05527 for scheme.
• See also Diethyl acetone-1,3-dicarboxylate, A10933.