2-Hydroxypyridine

• Catalog No.: A14522
• CAS Number: 142-08-5
• M. F.: C5H5NO
• M. W.: 95.0993
• Purity: 98+%

SYNONYMS

• Title: 2-羟基吡啶
• IUPAC name: pyridin-2-ol
• IUPAC Traditional name: 2-pyridone
• Synonyms: 2-Pyridinol; 2(1H)-Pyridone

DATABASE IDS

• EC Number: 205-520-3
• MDL Number: MFCD00006268
• Beilstein Number: 105786
• CAS Number: 142-08-5

PROPERTIES

• Purity: 98+%
• Boiling Point: 280-281°C
• Density: 1.39
• Flash Point: 210°C(410°F)
• Melting Point: 102-111°C
• GHS Hazard statements: H301-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P261-P301+P310-P305+P351+P338-P302+P352-P405-P501A
• Risk Statements: 25-36/37/38
• RTECS: UV1144050
• Safety Statements: 26-36/37-45
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN2811
• Packing Group: III

REFERENCES

• Bifunctional catalyst for a wide variety of acylation reactions. See, for example: J. Chem. Soc. (C), 89 (1969).
• Reacts with SOCl₂ to form di-2-pyridyl sulfite, a useful reagent for in situ formation of N-sulfinylamines, nitriles, isocyanides and carbodiimides under mild conditions: Tetrahedron Lett., 27, 1925 (1986).
• For use of 2-pyridyl esters as active esters in peptide coupling, see: J. Chem. Soc.(C), 2896 (1971); Chem. Ber., 118, 468 (1985). The group can be introduced on to the N-protected peptide using DCC in pyridine, and is displaced by the amino-residue under mild conditions. For peptide reagents, see Appendix 6. Similar methodology has also been used in an improved preparation of trichloroethyl esters: Synthesis, 24 (1979).