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2,2,2-Trifluoroacetamide_Molecular_structure_CAS_354-38-1)
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2,2,2-Trifluoroacetamide

Catalog No. A14451 Name Alfa Aesar
CAS Number 354-38-1 Website
M. F. C2H2F3NO Telephone
M. W. 113.0385896 Fax
Purity 97% Email
Storage Chembase ID: 8126

SYNONYMS

Title
2,2,2-三氟乙酰胺
IUPAC name
trifluoroacetamide
IUPAC Traditional name
trifluoroacetamide

DATABASE IDS

Beilstein Number 1753625
CAS Number 354-38-1
MDL Number MFCD00008008
EC Number 206-559-9

PROPERTIES

Purity 97%
Boiling Point 162-164°C
Melting Point 70-75°C
GHS Pictograms GHS07
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
GHS Precautionary statements P261-P305+P351+P338-P302+P352-P321-P405-P501A
Risk Statements 36/37/38
Safety Statements 26-37
TSCA Listed

DETAILS

REFERENCES

  • Has been used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group: Synthesis, 941 (1984). For improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups, see: Synth. Commun., 18, 791 (1988). The method has been further extended by the use of ɑ-bromo esters to provide a high yielding route to ɑ-amino acids: J. Org. Chem., 56, 420 (1991):