(Chloromethyl)trimethylsilane

• Catalog No.: A14303
• CAS Number: 2344-80-1
• M. F.: C4H11ClSi
• M. W.: 122.66864
• Purity: 98%

SYNONYMS

• Title: (氯甲基)三甲基硅烷
• IUPAC name: (chloromethyl)trimethylsilane
• IUPAC Traditional name: (chloromethyl)trimethylsilane

DATABASE IDS

• EC Number: 219-058-5
• CAS Number: 2344-80-1
• MDL Number: MFCD00000878
• Beilstein Number: 906705

PROPERTIES

• Purity: 98%
• Boiling Point: 97-98°C
• Density: 0.886
• Flash Point: -2°C(28°F)
• Refractive Index: 1.4180
• GHS Hazard statements: H224-H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• European Hazard Symbols: Flammable (F)
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 11-36/37/38
• Safety Statements: 9-16-23-26-33-37
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN1993
• Packing Group: II

REFERENCES

• For a review of the chemistry of chloromethyltrimethylsilane, see: Synthesis, 717 (1985).
• Treatment with s-BuLi at -78^o gives ɑ-lithio-ɑ-chloromethyltrimethylsilane which reacts with aldehydes and ketones to give ɑ?-epoxy silanes, readily hydrolyzed to homologated aldehydes: Tetrahedron, 39, 867 (1983):
  
• Metallation gives useful precursors of various organosilicon compounds. For use of the Grignard in the olefination of ketones, see: J. Org. Chem., 39, 3264 (1974); 52, 281 (1987). For Ni-catalyzed reaction of the Grignard with allylic dithioacetals, see: J. Org. Chem., 53, 5582 (1988); Org. Synth. Coll., 9, 727 (1998); for an example with reaction scheme, see trans-Cinnamaldehyde, A14689.