2-(Chloromethyl)quinoline hydrochloride

• Catalog No.: A14102
• CAS Number: 3747-74-8
• M. F.: C10H9Cl2N
• M. W.: 214.09116
• Purity: 97%

SYNONYMS

• Title: 2-(氯甲基)喹啉 盐酸盐
• IUPAC name: 2-(chloromethyl)quinoline hydrochloride
• IUPAC Traditional name: 2-(chloromethyl)quinoline hydrochloride
• Synonyms: alpha-Chloroquinaldine hydrochloride

DATABASE IDS

• MDL Number: MFCD00012734
• CAS Number: 3747-74-8
• Beilstein Number: 3565832
• EC Number: 223-145-3

PROPERTIES

• Purity: 97%
• Melting Point: 184-190°C
• GHS Hazard statements: H318-H315-H317-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 37/38-41-43
• Safety Statements: 24-26-37/39
• TSCA Listed: 否

REFERENCES

• As with 2-(Chloromethyl)pyridine hydrochloride, A10226, lithiation of the free base can be effected at the methylene group. Quinolylaziridines are formed on subsequent reaction with imines: J. Org. Chem., 60, 2279 (1995).
• The free base has been used in the protection of OH groups as 2-quinolinylmethyl (Qm) ethers which can be cleaved by aerial oxidation in the presence of Cu(II): J. Org. Chem., 55, 5344 (1990), or by photolysis: Tetrahedron, 48, 10563 (1992). The protection of thiols has also been reported, as the Qm thioethers, which can be cleaved with Fe(III) or Cu(II): Chem. Lett., 803 (1993).