Diethyl acetamidomalonate

• Catalog No.: A14048
• CAS Number: 1068-90-2
• M. F.: C9H15NO5
• M. W.: 217.2191
• Purity: 98+%

SYNONYMS

• Title: 乙酰氨基丙二酸二乙酯
• IUPAC name: 1,3-diethyl 2-acetamidopropanedioate
• IUPAC Traditional name: 1,3-diethyl 2-acetamidopropanedioate
• Synonyms: Acetamidomalonic acid diethyl ester

DATABASE IDS

• CAS Number: 1068-90-2
• MDL Number: MFCD00009146
• EC Number: 213-952-9
• Beilstein Number: 783883

PROPERTIES

• Purity: 98+%
• Boiling Point: 185°C/20mm
• Melting Point: 96-99°C
• GHS Hazard statements: H303
• GHS Precautionary statements: P312
• RTECS: OO0360000
• TSCA Listed: 是

REFERENCES

• Intermediate for synthesis of racemic amino acids, by reaction with an electrophile, e.g alkyl halide, followed by hydrolysis and decarboxylation. The reactivity can be reversed by conversion to the dehydro-derivative, which then undergoes nucleophilic attack with alkyllithiums, Grignards, malonate anion, etc.: Angew. Chem. Int. Ed., 21, 203 (1982):
  
• Substituents can also be introduced by Michael addition to a wide variety of acceptors: Synth. Commun., 18, 367 (1988).
• For use in a novel pyrrole synthesis, see 1,4-Dichloro-2-butyne, A13300.
• Compare also Diethyl formamidomalonate, L01189.