Hydrazine monohydrate

• Catalog No.: A14005
• CAS Number: 7803-57-8
• M. F.: H6N2O
• M. W.: 50.06044
• Purity: 98+%

SYNONYMS

• Title: 水合肼
• IUPAC name: hydrazine hydrate
• IUPAC Traditional name: hydrazine hydrate

DATABASE IDS

• Merck Index: 144771
• CAS Number: 7803-57-8
• EC Number: 206-114-9
• MDL Number: MFCD00149931

PROPERTIES

• Purity: 98+%
• Boiling Point: 120-121°C
• Density: 1.027
• Flash Point: 75°C(167°F)
• Melting Point: -52°C
• Refractive Index: 1.4310
• GHS Hazard statements: H301-H310-H330-H317-H350-H314-H318-H400-H410-H227
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501A
• Risk Statements: 45-23/24/25-34-43-50/53
• RTECS: MV4590000
• Safety Statements: 53-45-60-61
• TSCA Listed: 是
• Hazard Class: 8
• UN Number: UN2030
• Packing Group: II

REFERENCES

• Forms stable, water-free solid complexes consisting of one hydrazine molecule associated with one molecule of hydroquinone or two molecules of 4-methoxyphenol. These have potential as replacements for the very hazardous anhydrous hydrazine, e.g. in the solid state reaction with esters to give pure hydrazides: J. Chem. Soc., Chem. Commun., 1531, (1995).
• Diimide precursor: for generation of diimide by oxidation with O₂, and use in selective reduction of a double bond in the presence of a cyclopropane ring, see: J. Chem. Soc., Chem. Commun., 525 (1973). Review of diimide reductions: Org. React., 40, 91 (1991). See also Hydroxylamine-O-sulfonic acid, A12560.
• In the Wolff-Kishner carbonyl to methylene reduction (heating with hydrazine and alkali hydroxide), diethylene glycol is now the usual solvent (the Huang Minlon modification): J. Am. Chem. Soc., 68, 2487 (1946); Org. Synth. Coll., 4, 510 (1963). The reduction has also been performed at ambient temperature by the use of KO-t-Bu in DMSO: J. Am. Chem. Soc., 84, 1734 (1962). See also Isatin, A12468 for an analogous reduction.
• In the presence of Rh on carbon, nitrobenzene is selectively reduced to phenylhydroxylamine: Org. Synth. Coll., 8, 16 (1993).
• For a brief feature on uses of the reagent in synthesis, see: Synlett, 2445 (2004).