Bromoacetonitrile

• Catalog No.: A13933
• CAS Number: 590-17-0
• M. F.: C2H2BrN
• M. W.: 119.94798
• Purity: 96%

SYNONYMS

• Title: 溴乙腈
• IUPAC name: 2-bromoacetonitrile
• IUPAC Traditional name: 2-bromoacetonitrile

DATABASE IDS

• CAS Number: 590-17-0
• MDL Number: MFCD00001884
• EC Number: 209-672-1
• Beilstein Number: 956569

PROPERTIES

• Purity: 96%
• Boiling Point: 150°C
• Density: 1.722
• Flash Point: 81°C(178°F)
• Refractive Index: 1.4800
• GHS Hazard statements: H300-H310-H330-H314-H318-H227
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501A
• Risk Statements: 23/24/25-34
• RTECS: AL7970000
• Safety Statements: 26-27-36/37/39-45
• TSCA Listed: 否
• Hazard Class: 8
• UN Number: UN2922
• Packing Group: II

REFERENCES

• Phenols can be protected (K₂CO₃, acetone) as their cyanomethyl ethers which can be cleaved by hydrogenation of the nitrile: Tetrahedron Lett., 34, 7567 (1993).
• The Reformatsky-type reaction with cyclohexanone is more successful in the presence of a Zn/Ag couple than with the conventional Zn-Cu couple: Synth. Commun., 19, 2355 (1989). Good yields of ?-hydroxy nitriles have also been achieved from aldehydes and ketones using Zn and TMS chloride: Tetrahedron Lett., 31, 2205 (1990). The condensation with aldehydes can also be mediated by active Ni: Tetrahedron Lett., 26, 155 (1985). The reaction with aldehydes in the presence of Zn and tri-n-butylphosphine gives ɑ?-unsaturated nitriles directly: Synth. Commun., 20, 3277 (1990).