Ethyl carbazate

• Catalog No.: A13860
• CAS Number: 4114-31-2
• M. F.: C3H8N2O2
• M. W.: 104.10782
• Purity: 97%

SYNONYMS

• Title: 肼基甲酸乙酯
• IUPAC name: ethoxycarbohydrazide
• IUPAC Traditional name: ethoxycarbohydrazide
• Synonyms: Ethyl hydrazinocarboxylate; Ethoxycarbonylhydrazine

DATABASE IDS

• Beilstein Number: 878265
• CAS Number: 4114-31-2
• MDL Number: MFCD00007595
• EC Number: 223-903-3

PROPERTIES

• Purity: 97%
• Boiling Point: 85-86°C/7mm
• Flash Point: 86°C(186°F)
• Melting Point: 44-47°C
• GHS Hazard statements: H300-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P280H-P305+P351+P338-P309-P310
• Risk Statements: 25-36/37/38
• RTECS: FE2545000
• Safety Statements: 26-36/37-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN2811
• Packing Group: III

REFERENCES

• Forms crystalline ethoxycarbonyl hydrazones with aldehydes and ketones. With o-acylphenols, Pb(OAc)₄ treatment of the resulting hydrazone results in replacement of the phenolic OH with ethoxycarbonyl, providing a route to ethyl o-acylbenzoates: Tetrahedron Lett ., 31, 6781 (1990).
• Reaction with methyl ketones, followed by treatment with SOCl₂, leads to 4-substituted 1,2,3-thiadiazoles: J. Am. Chem. Soc., 77, 5359 (1955). In the presence of base, these readily lose N₂ to give alkynethiolates: Can. J. Chem., 46, 1057 (1968):
  
• More recently, this sequence has been used in the synthesis of dendrimers from 1,3,5-triacetylbenzene: J. Chem. Soc., Perkin 1, 2203 (1994).