4-Methoxybenzenesulfonyl chloride

• Catalog No.: A13788
• CAS Number: 98-68-0
• M. F.: C7H7ClO3S
• M. W.: 206.64668
• Purity: 98+%

SYNONYMS

• Title: 4-甲氧基苯磺酰氯
• IUPAC name: 4-methoxybenzene-1-sulfonyl chloride
• IUPAC Traditional name: 4-methoxybenzenesulfonyl chloride
• Synonyms: p-Anisolesulfonyl chloride

DATABASE IDS

• EC Number: 202-692-1
• Beilstein Number: 609005
• MDL Number: MFCD00007446
• CAS Number: 98-68-0

PROPERTIES

• Purity: 98+%
• Boiling Point: 119-122°C/0.4mm
• Flash Point: >110°C(230°F)
• Melting Point: 37-42°C
• GHS Hazard statements: H314-H318
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• Risk Statements: 34
• Safety Statements: 26-36/37/39-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否
• Hazard Class: 8
• UN Number: UN3261
• Packing Group: II

REFERENCES

• Amines and other N-functions can be protected as 4-methoxybenzenesufonyl (PMBS, Mps) derivatives: Chem. Pharm. Bull., 29, 2592 (1981), useful for the imidazole in histidines, stable to TFA and HBr/AcOH: Bull. Chem. Soc. Jpn., 47, 3146 (1974); J. Org. Chem., 45, 547 (1980); deprotection in TFA is promoted by dimethyl sulfide: J. Chem. Soc., Chem. Commun., 955 (1979). For deprotection of PMBS-indoles using Mg in methanol, see: J. Org. Chem., 62, 6519 (1997).
• Also used for protection of the guanidino function of arginine residues in peptide synthesis. The sulfonamide is cleaved by triflic acid under less drastic conditions than tosyl groups: Chem. Pharm. Bull., 24, 1568 (1976). Compare also 4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride, L11829. See Appendix 6.