Trimethyl orthoformate

• Catalog No.: A13760
• CAS Number: 149-73-5
• M. F.: C4H10O3
• M. W.: 106.1204
• Purity: 99%

SYNONYMS

• Title: 原甲酸三甲酯
• IUPAC name: trimethoxymethane
• IUPAC Traditional name: trimethyl orthoformate
• Synonyms: Orthoformic acid trimethyl ester; Methyl orthoformate

DATABASE IDS

• Beilstein Number: 969215
• Merck Index: 146884
• MDL Number: MFCD00008483
• EC Number: 205-745-7
• CAS Number: 149-73-5

PROPERTIES

• Purity: 99%
• Boiling Point: 101-102°C
• Density: 0.968
• Flash Point: 15°C(59°F)
• Melting Point: -53°C
• Refractive Index: 1.3790
• GHS Hazard statements: H225-H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• European Hazard Symbols: Flammable (F)
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 11-36/37/38
• RTECS: RM6650000
• Safety Statements: 26-37-60
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN3272
• Packing Group: II

REFERENCES

• For further reactions of alkyl orthoformates, see Triethyl orthoformate, A13587.
• Protects the cis-2,3-diol system of ribonucleosides as their methoxymethylene acetals (cyclic orthoformates), readily hydrolyzed by mild acid: Synthesis, 408 (1985).
• In the presence of HCl, is an alternative to formic acid in the synthesis of benzoxazoles from ortho-amino phenols: Org. Prep. Proced. Int., 22, 613 (1990).
• Reagent for the acid-catalyzed conversion of ketones to their methyl enol ethers in good yield: Synthesis, 38 (1974). For an example, see: Org. Synth. Coll., 8, 357 (1993).