2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline

• Catalog No.: A13724
• CAS Number: 16357-59-8
• M. F.: C14H17NO3
• M. W.: 247.28968
• Purity: 99%

SYNONYMS

• Title: 2-乙氧基-1-乙氧基羰基-1,2-二氢喹啉
• IUPAC name: ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate
• IUPAC Traditional name: ethyl 2-ethoxy-2H-quinoline-1-carboxylate
• Synonyms: EEDQ; N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

DATABASE IDS

• Merck Index: 143518
• Beilstein Number: 533048
• EC Number: 240-418-2
• CAS Number: 16357-59-8
• MDL Number: MFCD00006703

PROPERTIES

• Purity: 99%
• Boiling Point: 125-128°C/0.1mm
• Melting Point: 63-66°C
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• RTECS: VB2010000
• Safety Statements: 26-37
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是

REFERENCES

• Reagent for peptide coupling. Reaction proceeds via the anhydride of the acid component: J. Am. Chem. Soc., 90, 823, 1651 (1968); Int. J. Pept. Prot. Res., 26, 493 (1985). See Appendix 6.
• For activation of ɑ -hydroxy acids, see: Tetrahedron Lett, 40, 3435 (1999) . Also used for the mild esterification of alcohols, e.g. for introduction of the levulinate protecting group (see Levulinic acid, A10813): Tetrahedron Lett., 23, 2615 (1982). For a useful esterification technique applicable to primary, secondary and tertiary alcohols, see: J. Org. Chem., 60, 7072 (1995).