1-Chloro-4-fluorobenzene

• Catalog No.: A13690
• CAS Number: 352-33-0
• M. F.: C6H4ClF
• M. W.: 130.5473632
• Purity: 98%

SYNONYMS

• Title: 1-氯-4-氟苯
• IUPAC name: 1-chloro-4-fluorobenzene
• IUPAC Traditional name: P-chlorofluorobenzene
• Synonyms: 4-Chlorofluorobenzene

DATABASE IDS

• MDL Number: MFCD00000603
• EC Number: 206-521-1
• Beilstein Number: 1904542
• CAS Number: 352-33-0

PROPERTIES

• Density: 1.228
• Flash Point: 29°C(84°F)
• Melting Point: -22°C
• Refractive Index: 1.4950
• Boiling Point: 129-130°C
• GHS Hazard statements: H226-H332-H315-H319-H335
• European Hazard Symbols: X
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 10-20-36/37/38
• Safety Statements: 26-36/37
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN1993
• Packing Group: III
• Purity: 98%

REFERENCES

• Lithiation with LDA occurs mainly ortho to F; subsequent carboxylation gives 5-chloro-2-fluorobenzoic acid in moderate yield: Tetrahedron Lett., 33, 7495 (1992). The selectivity is improved by the use of the superbasic combination of n-BuLi and KO-t-Bu, and the yield is increased to 86%: Tetrahedron Lett., 37, 6551 (1996).