2-Bromopyridine

• Catalog No.: A13241
• CAS Number: 109-04-6
• M. F.: C5H4BrN
• M. W.: 157.99596
• Purity: 99%

SYNONYMS

• Title: 2-溴吡啶
• IUPAC name: 2-bromopyridine
• IUPAC Traditional name: 2-bromopyridine

DATABASE IDS

• EC Number: 203-641-6
• Beilstein Number: 105789
• MDL Number: MFCD00006219
• CAS Number: 109-04-6

PROPERTIES

• Purity: 99%
• Boiling Point: 192-194°C
• Density: 1.625
• Flash Point: 97°C(207°F)
• Refractive Index: 1.5720
• GHS Hazard statements: H301-H310-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P280H-P305+P351+P338-P309-P310
• Risk Statements: 24/25-36/37/38
• RTECS: US3850000
• Safety Statements: 26-36/37-45
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN2810
• Packing Group: II

REFERENCES

• Reaction with n-BuLi gives 2-lithio-pyridine. Subsequent reaction at low temperatures with PCl₃ gives, as the major product, 2,2'-bipyridine, along with a low yield of the expected tris(2-pyridyl)phosphine. POCl₃ or SOCl₂ also promote the symmetrical coupling reaction: Heteroatom. Chem., 5, 409 (1994). In contrast, reaction with LDA in THF at -78^o results in lithiation at the 3-position, giving access to 3-substituted 2-bromopyridines: Synthesis, 235, 237 (1982). See also: Org. Lett., 3, 835 (2001).
• Bromopyridines can be converted to the Grignards by Mg exchange with i-PrMgCl: Tetrahdron Lett., 40, 4339 (1999).