Furan

• Catalog No.: A13102
• CAS Number: 110-00-9
• M. F.: C4H4O
• M. W.: 68.07396
• Purity: 99%, stab. with ca 250ppm BHT

SYNONYMS

• Title: 呋喃
• IUPAC name: furan
• IUPAC Traditional name: furan

DATABASE IDS

• CAS Number: 110-00-9
• MDL Number: MFCD00003222
• Beilstein Number: 103221
• EC Number: 203-727-3
• Merck Index: 144296

PROPERTIES

• Purity: 99%, stab. with ca 250ppm BHT
• Boiling Point: 32-33°C
• Density: 0.936
• Flash Point: -35°C(-31°F)
• Melting Point: -86°C
• Refractive Index: 1.4220
• GHS Hazard statements: H224-H350-H341-H373-H302-H332-H315-H412
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Highly flammable (F+)
• GHS Precautionary statements: P210-P241-P260-P303+P361+P353-P405-P501A
• Risk Statements: 45-12-19-20/22-38-48/22-68-52/53
• RTECS: LT8524000
• Safety Statements: 53-45-61
• Storage Warning: Air & Light Sensitive
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN2389
• Packing Group: I

REFERENCES

• Diels-Alder cycloadditions of furans with reactive dienophiles, followed by dehydration of the resulting 7-oxabicyclo[2.2.1]heptenes generate benzenes, often with unusual substitution patterns; review: Heterocycles, 22, 875 (1984). Adducts of furans with alkynes can be deoxygenated to give aromatics, by reduction with a low-valent Ti reagent: Synthesis, 787 (1984).
• Lithiation occurs at the 2-position. For the formation of furfuryl propargyl ethers and their subsequent base catalyzed intramolecular Diels-Alder cyclization to isobenzofuran derivatives, see: J. Org. Chem., 60,6168 (1995). 2,5-Dilithiation can be effected with n-BuLi - TMEDA: J. Chem. Soc., Perkin 1, 887 (1977), or n-BuLi - KO-t-Bu: Synthesis, 316 (1988). A Barbier-type reaction has been reported in which furan is reacted with a lithium carboxylate in the presence of Li metal and t-butyl chloride with sonication: J. Org. Chem., 60, 8 (1995), providing an easy access to 2-furyl ketones.