Benzyl carbazate

• Catalog No.: A13005
• CAS Number: 5331-43-1
• M. F.: C8H10N2O2
• M. W.: 166.1772
• Purity: 98+%

SYNONYMS

• Title: 肼基甲酸苄酯
• IUPAC name: (benzyloxy)carbohydrazide
• IUPAC Traditional name: benzyloxycarbohydrazide
• Synonyms: Benzyl Hydrazinocarboxylate; Benzyloxycarbonylhydrazine

DATABASE IDS

• MDL Number: MFCD00041890
• CAS Number: 5331-43-1
• Beilstein Number: 1952982
• EC Number: 226-230-3

PROPERTIES

• Purity: 98+%
• Melting Point: 66-70°C
• GHS Hazard statements: H318-H315-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 37/38-41
• RTECS: MV1724950
• Safety Statements: 26-37/39
• TSCA Listed: 是

REFERENCES

• Reagent for preparation of benzyloxycarbonyl (Z, Cbz) hydrazides of carboxylic acids, particularly N-protected amino acids. Subsequent hydrogenolysis gives the hydrazide which can be converted to the azide for coupling with a further amino acid residue by the azide method: J. Am. Chem. Soc., 74, 470 (1952); 87, 620 (1965); see Appendix 6:
  
• Has also been used in a similar manner for the preparation of simple acyl or sulfonyl hydrazides avoiding diacylation; the residual benzyl group is removable by hydrogenolysis: Synthesis, 244 (1980).