Benzhydrol

• Catalog No.: A12884
• CAS Number: 91-01-0
• M. F.: C13H12O
• M. W.: 184.23378
• Purity: 99%

SYNONYMS

• Title: 二苯基甲醇
• IUPAC name: diphenylmethanol
• IUPAC Traditional name: benzhydrol
• Synonyms: Diphenylcarbinol; Diphenylmethanol

DATABASE IDS

• Beilstein Number: 1424379
• CAS Number: 91-01-0
• EC Number: 202-033-8
• MDL Number: MFCD00004488
• Merck Index: 141090

PROPERTIES

• Purity: 99%
• Boiling Point: 297-298°C
• Flash Point: 160°C(320°F)
• Melting Point: 64-68°C
• GHS Hazard statements: H303-H402-H412
• GHS Precautionary statements: P273-P312-P501A
• Risk Statements: 52/53
• RTECS: DC7452000
• Safety Statements: 61
• TSCA Listed: 是

REFERENCES

• The protection of OH groups as benzhydryl ethers can be catalyzed by sulfuric acid: Org. Synth. Coll., 4, 72 (1963); Angew. Chem. Int. Ed., 15, 281 (1976). See also Benzhydryl bromide, L02211. Thiols, e.g. in cysteine residues in peptide synthesis, can be protected as thioethers in the presence of TFA or HBr/AcOH: J. Chem. Soc. (C), 2683 (1970). The group can be cleaved by TFA in the presence of a cation scavenger, e.g. phenol or anisole (same ref.), or by Na in liquid NH₃: J. Am. Chem. Soc., 84, 3887 (1962). See Appendix 6.
• Carboxyl groups can be protected by esterification in benzene with tosic acid catalyst. Deprotection can be effected with the same catalyst by refluxing in toluene, which undergoes electrophilic alkylation: Tetrahedron Lett., 37, 1965 (1996).