Thiourea

• Catalog No.: A12828
• CAS Number: 62-56-6
• M. F.: CH4N2S
• M. W.: 76.12086
• Purity: 99%

SYNONYMS

• Title: 硫脲
• IUPAC name: thiourea
• IUPAC Traditional name: thion
• Synonyms: Thiocarbamide

DATABASE IDS

• CAS Number: 62-56-6
• Beilstein Number: 605327
• MDL Number: MFCD00008067
• EC Number: 200-543-5
• Merck Index: 149367

PROPERTIES

• Risk Statements: 22-40-51/53-63
• RTECS: YU2800000
• Safety Statements: 36/37-61
• TSCA Listed: 是
• Hazard Class: 9
• UN Number: UN3077
• Packing Group: III
• GHS Hazard statements: H351-H361-H302-H411-H401
• European Hazard Symbols: X
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P280H-P273
• Purity: 99%
• Density: 1.405
• Melting Point: 172-178°C

REFERENCES

• Reagent for the conversion of alkyl halides to thiols by base hydrolysis of the isothiouronium salts; see also N-Acetylthiourea, B21198. Cleavage of isothiouronium salts with base and alkylation of the resulting thiolate has been used as a convenient synthesis of unsymmetrical sulfides: Synth. Commun., 14, 209 (1984).
• Epoxides are converted to episulfides: J. Org. Chem., 26, 3467 (1961). The 2,3-epoxy alcohols resulting from the Sharpless enantioselective epoxidation can be converted to the corresponding episulfides with retention at both centers, using Ti(O-i-Pr)₄ as mediator: J. Org. Chem., 53, 4114 (1988).
• Widely used in heterocyclic syntheses, e.g. of thiazoles and pyrimidines.
• Has been used in a convenient synthesis of isothiocyanates from oximes via the nitrile oxide: Tetrahedron Lett., 34, 8283 (1993); see also Benzaldoxime, A12053: