Di-tert-butyl malonate

• Catalog No.: A12774
• CAS Number: 541-16-2
• M. F.: C11H20O4
• M. W.: 216.2741
• Purity: 98+%, stab. with potassium carbonate

SYNONYMS

• Title: 丙二酸二叔丁酯
• IUPAC name: 1,3-di-tert-butyl propanedioate
• IUPAC Traditional name: 1,3-di-tert-butyl propanedioate
• Synonyms: Malonic acid di-tert-butyl ester

DATABASE IDS

• EC Number: 208-769-6
• Merck Index: 143034
• MDL Number: MFCD00008810
• Beilstein Number: 1781766
• CAS Number: 541-16-2

PROPERTIES

• Purity: 98+%, stab. with potassium carbonate
• Boiling Point: 65-67°C/1mm
• Density: 0.965
• Flash Point: 88°C(190°F)
• Melting Point: -6°C
• Refractive Index: 1.4190
• GHS Hazard statements: H317-H227
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P210-P261-P302+P352-P321-P403+P235-P501A
• Risk Statements: 43
• Safety Statements: 23-24-37
• TSCA Listed: 是

REFERENCES

• Alternative to Diethyl malonate, A15468, permitting removal of the t-butyl groups and decarboxylation by thermolysis in the presence of mild acid: J. Am. Chem. Soc., 74, 831 (1952). In the presence of Cu(OAc)₂, condenses with paraformaldehyde to form the useful electrophilic alkene, di-t-butyl methylenemalonate: J. Org. Chem., 48, 3603 (1983), which is more stable than the ethyl or methyl esters, and can be stored for some weeks at room temperature. For references to use of methylenemalonic esters in Michael addition and cycloaddition reactions, see: Org. Synth. Coll., 7, 142 (1990).