Tri-n-butylphosphine

• Catalog No.: A12649
• CAS Number: 998-40-3
• M. F.: C12H27P
• M. W.: 202.316541
• Purity: 95%

SYNONYMS

• Title: 三正丁基膦
• IUPAC name: tributylphosphane
• IUPAC Traditional name: tributylphosphine

DATABASE IDS

• EC Number: 213-651-2
• CAS Number: 998-40-3
• MDL Number: MFCD00009462
• Beilstein Number: 1738261

PROPERTIES

• Purity: 95%
• Boiling Point: 240°C
• Density: 0.820
• Flash Point: >93°C(199°F)
• Melting Point: -65°C
• Refractive Index: 1.4620
• GHS Hazard statements: H250-H252-H301-H314-H318-H411-H401
• European Hazard Symbols: X
• European Hazard Symbols: Corrosive (C)
• European Hazard Symbols: Flammable (F)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P422A-P501A
• Risk Statements: 17-22-34-51/53
• RTECS: SZ3270000
• Safety Statements: 7-17-26-36/37/39-45
• Storage Warning: Air & Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 4.2
• UN Number: UN3254
• Packing Group: I

REFERENCES

• A useful alternative to Triphenylphosphine, L02502 in many applications. Advantages include its greater reactivity and the water-solubility of the by-product phosphine oxide, simplifying its removal.
• In combination with phenyl isocyanate and a Pd catalyst, converts cinnamyl alcohol directly to a phosphorane, which reacts with aldehydes to give conjugated dienes: Chem. Lett., 1449 (1988):
  
• Can behave as a hypernucleophilic catalyst in acylation reactions, with similar results to 4-(Dimethylamino)pyridine, A13016: J. Am. Chem. Soc., 115, 3358 (1993).
• Effective catalyst for the Baylis-Hillman reaction with less tendency than the usual DABCO (1,4-Diazabicyclo[2.2.2]octane, A14003) to promote aldol type side reactions: J. Org. Chem., 62, 1521 (1997).
• For example of its use in Mitsunobu-type reactions, see Diisopropyl azodicarboxylate, L10386.