1-Methylimidazole

• Catalog No.: A12575
• CAS Number: 616-47-7
• M. F.: C4H6N2
• M. W.: 82.10384
• Purity: 99%

SYNONYMS

• Title: 1-甲基咪唑
• IUPAC name: 1-methyl-1H-imidazole
• IUPAC Traditional name: 1-methylimidazole

DATABASE IDS

• MDL Number: MFCD00005292
• Beilstein Number: 105197
• EC Number: 210-484-7
• CAS Number: 616-47-7

PROPERTIES

• Purity: 99%
• Boiling Point: 195-197°C
• Density: 1.031
• Flash Point: 92°C(197°F)
• Melting Point: -6°C
• Refractive Index: 1.4970
• GHS Hazard statements: H314-H302-H312-H227
• European Hazard Symbols: X
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P210-P260-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 21/22-34
• RTECS: NI7000000
• Safety Statements: 1/2-26-36-45
• Storage Warning: Hygroscopic
• TSCA Listed: 是
• Hazard Class: 8
• UN Number: UN2922
• Packing Group: III

REFERENCES

• Useful base for peptide coupling, etc. See, e.g.: J. Chem. Soc., Chem. Commun., 2223 (1995). For peptide reagents, see Appendix 6.
• Undergoes lithiation at the 2-position. Reaction of the Li derivative with ketones followed by dehydration with acetic anhydride is a good route to 2-alkylideneimidazoles: Synthesis, 78 (1990). Likewise, reaction with benzonitrile gives the 2-benzoyl derivative, the carbonyl group of which undergoes Wittig methylenation: Synth. Commun., 20, 321 (1990).
• Reacts with acid chlorides, including chloroformates, to give N-acylimidazolium salts, which are useful reagents for the acylation of, for example, amino acids: Bull. Soc. Chim. Fr., 1021 (1973).