Pyridine

• Catalog No.: A12005
• CAS Number: 110-86-1
• M. F.: C5H5N
• M. W.: 79.0999
• Purity: 99+%

SYNONYMS

• Title: 吡啶
• IUPAC name: pyridine
• IUPAC Traditional name: pyridine

DATABASE IDS

• MDL Number: MFCD00011732
• Beilstein Number: 103233
• CAS Number: 110-86-1
• EC Number: 203-809-9
• Merck Index: 147970

PROPERTIES

• Purity: 99+%
• Boiling Point: 115°C
• Density: 0.978
• Flash Point: 20°C(68°F)
• Melting Point: -42°C
• Refractive Index: 1.5100
• Solubility: Miscible with water, alcohol, ether, pet ether, oils
• GHS Hazard statements: H225-H311-H302-H332
• European Hazard Symbols: X
• European Hazard Symbols: Flammable (F)
• GHS Precautionary statements: P210-P241-P303+P361+P353-P361-P405-P501A
• Risk Statements: 11-20/21/22
• RTECS: UR8400000
• Safety Statements: 26-28
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN1282
• Packing Group: II

REFERENCES

• Widely used as a base and nucleophilic catalyst in acylations, sulfonylations, etc. See also 4-(Dimethylamino)pyridine, A13016.
• Reacts with thionyl chloride to give N-(4-pyridyl)pyridinium chloride hydrochloride, a useful intermediate for the preparation of 4-substituted pyridines by nucleophilic displacement. Thus, reaction with sulfite ion gives the sulfonate: Org. Synth. Coll., 5, 977 (1973). Similarly, pyridine can be activated tosubstitution at the 4-position by reaction with Ethyl chloroformate, L06311, or tert-Butyldimethylsilyl trifluoromethanesulfonate, A12174. The acyl or silyl pyridinium salt then reacts with Grignards or organocuprates, to give 4-substituted dihydropyridines which can readily be rearomatized: Bull. Chem. Soc. Jpn., 57, 1994 (1984).
• For use in Cr(VI) oxidation reactions, see Chromium(VI) oxide, 12522.