1-Nitropropane

• Catalog No.: A11975
• CAS Number: 108-03-2
• M. F.: C3H7NO2
• M. W.: 89.09318
• Purity: 98%

SYNONYMS

• Title: 1-硝基丙烷
• IUPAC name: 1-nitropropane
• IUPAC Traditional name: 1-nitropropane

DATABASE IDS

• EC Number: 203-544-9
• MDL Number: MFCD00007407
• CAS Number: 108-03-2
• Merck Index: 146627
• Beilstein Number: 506236

PROPERTIES

• Purity: 98%
• Boiling Point: 131-132°C
• Density: 0.998
• Flash Point: 34°C(93°F)
• Melting Point: -108°C
• Refractive Index: 1.4020
• GHS Hazard statements: H226-H302-H312-H332
• European Hazard Symbols: X
• GHS Precautionary statements: P210-P241-P303+P361+P353-P302+P352-P403+P235-P501A
• Risk Statements: 10-20/21/22
• RTECS: TZ5075000
• Safety Statements: 2-9
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN2608
• Packing Group: III

REFERENCES

• For an example of condensation with an aldehyde (Henry reaction), promoted by KF in IPA, see: Org. Synth. Coll., 9, 242 (1998). Other conditions recommended for the Henry reaction include the use of the basic ion-exchange resin Amberlyst? A-21, A17956: Liebigs Ann. Chem., 1994, 1235; J. Org. Chem., 59, 5466 (1994); Tetrahedron, 52, 1677 (1996), and aqueous NaOH in the presence of a surfactant-type catalyst (hexadecyltrimethylammmonium chloride): J. Org. Chem., 62, 425 (1997). Improved yields in condensations with cycloalkanones were obtained by the use of high pressure: Angew. Chem. Int. Ed., 23, 617 (1984).
• Primary nitro-compounds are converted to nitrile oxides by reaction with POCl₃ in pyridine: J. Org. Chem., 42, 3956 (1977). For example of 1,3-dipolar addition reaction of the nitrile oxide to give an isoxazole, see Ethyl (E)-3-(1-pyrrolidinyl)crotonate, L00461.
• For discussion of conditions for formation and chemistry of the ɑɑ- and ɑ?- dilithio derivatives, see: Encyclopedia of Reagents for Organic Synthesis, L. A. Paquette, Ed., Wiley, Chichester (1995), vol. 3, p. 1946.