N-Methylformanilide

• Catalog No.: A11829
• CAS Number: 93-61-8
• M. F.: C8H9NO
• M. W.: 135.16316
• Purity: 99%

SYNONYMS

• Title: N-甲基甲酰苯胺
• IUPAC name: N-methyl-N-phenylformamide
• IUPAC Traditional name: N-methylformanilide

DATABASE IDS

• CAS Number: 93-61-8
• MDL Number: MFCD00003283
• EC Number: 202-262-3
• Beilstein Number: 636496

PROPERTIES

• Purity: 99%
• Boiling Point: 242-244°C
• Density: 1.095
• Flash Point: 126°C(258°F)
• Melting Point: 9-13°C
• Refractive Index: 1.5610
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• Safety Statements: 26-37
• TSCA Listed: 是

REFERENCES

• Has also been used for the conversion of aryllithiums to aldehydes: J. Chem. Soc. (C), 1700 (1969).
• Component of Vilsmeier's original reagent for the formylation of reactive aromatics via the iminium salts: Ber., 60, 119 (1927); much used in earlier work, where N,N-Dimethylformamide, A13547, is often now preferred due to lower cost, greater thermal stability of the iminium salt and easier separation of the by-products (water-soluble in the case of DMF). The N-methylformanilide reagent is still occasionally preferred because of its higher electrophilic potential, although this may be partially offset by its greater steric demand. For examples of its use, see: Org. Synth. Coll., 3, 96 (1955); 4, 915 (1963). Review: Adv. Org. Chem., 9, 225 (1976). Monograph: Synthesis Using Vilsmeier Reagents, C. M. Marson, P. R. Giles, CRC Press, Boca Raton, FL (1994).