N-Ethyldiisopropylamine

• Catalog No.: A11801
• CAS Number: 7087-68-5
• M. F.: C8H19N
• M. W.: 129.24316
• Purity: 99%

SYNONYMS

• Title: N-乙基二异丙基胺
• IUPAC name: ethylbis(propan-2-yl)amine
• IUPAC Traditional name: N,N-diisopropylethylamine
• Synonyms: DIEA; N,N-Diisopropylethylamine

DATABASE IDS

• MDL Number: MFCD00008868
• EC Number: 230-392-0
• Beilstein Number: 605301
• CAS Number: 7087-68-5

PROPERTIES

• Purity: 99%
• Boiling Point: 126-127°C
• Density: 0.747
• Flash Point: 8°C(46°F)
• Melting Point: -46°C
• Refractive Index: 1.4135
• GHS Hazard statements: H225-H301-H314-H318-H402-H412
• European Hazard Symbols: X
• European Hazard Symbols: Corrosive (C)
• European Hazard Symbols: Flammable (F)
• GHS Precautionary statements: P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 11-22-34-52/53
• Safety Statements: 16-26-36/37/39-45-61
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN2733
• Packing Group: II

REFERENCES

• Hindered non-nucleophilic base with high proton affinity: Chem. Ber., 91, 380 (1958).
• Useful base in peptide coupling reactions: J. Am. Chem. Soc., 91, 6488 (1969). See Appendix 6.
• For use in the introduction of TBDMS protecting groups, see tert-Butyldimethylchlorosilane, A13064. Used in preparation of silyl enol ethers from both aldehydes and ketones: Helv. Chim. Acta, 60, 1801 (1977).
• Has been recommended as a base for the Horner-Wadsworth-Emmons olefination reaction, where the reagents contain groups sensitive to base-catalyzed epimerization or condensation. The reaction is carried out in the presence of LiCl, and gives high (E):(Z) ratios: Tetrahedron Lett., 25, 2183 (1984).