Chlorotriphenylmethane

• Catalog No.: A11799
• CAS Number: 76-83-5
• M. F.: C19H15Cl
• M. W.: 278.7754
• Purity: 98%

SYNONYMS

• Title: 三苯基氯甲烷
• IUPAC name: (chlorodiphenylmethyl)benzene
• IUPAC Traditional name: triphenylmethyl chloride
• Synonyms: Trityl chloride; Triphenylmethyl chloride

DATABASE IDS

• CAS Number: 76-83-5
• EC Number: 200-986-4
• MDL Number: MFCD00000813
• Beilstein Number: 397363

PROPERTIES

• Purity: 98%
• Boiling Point: 230-235°C/20mm
• Melting Point: 110-114°C
• GHS Hazard statements: H314-H318-H400-H410
• European Hazard Symbols: Corrosive (C)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P280-P273-P305+P351+P338-P309-P310
• Risk Statements: 34-50/53
• RTECS: PA6450000
• Safety Statements: 26-36/37/39-45-60-61
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 8
• UN Number: UN3261
• Packing Group: II

REFERENCES

• Reagent for protection of N, S and particularly O functions as trityl (Trt) derivatives, stable to a wide range of conditions, but readily cleaved by mild acid.
• For an improved method for O-tritylation in triethylamine in the presence of catalytic amounts of DMAP, see: Tetrahedron Lett., 95 (1979).
• Progressively more acid-labile protecting groups contain one, two or three p-methoxy-groups: 4-Methoxytrityl chloride, A10545, 4,4'-Dimethoxytrityl chloride, A11626, and 4,4',4''-Trimethoxytrityl chloride, L00629, respectively.
• For a one-pot procedure for the high yield, racemization-free N-tritylation of amino acids, by means of prior in situ O-silylation, see: J. Org. Chem., 47, 1324 (1982). N-Trt- derivatives of amino acids have also been converted to Leuchs' anhydrides by treatment with phosgene or triphosgene, and the products coupled with amino acid esters to give dipeptides in good yields without racemization: J. Org. Chem., 64, 2532 (1999). See also 9-Bromo-9-phenylfluorene, L14225.