Mesitylene-2-sulfonyl chloride

• Catalog No.: A11775
• CAS Number: 773-64-8
• M. F.: C9H11ClO2S
• M. W.: 218.70044
• Purity: 99%

SYNONYMS

• Title: 均三甲苯-2-磺酰氯
• IUPAC name: 2,4,6-trimethylbenzene-1-sulfonyl chloride
• IUPAC Traditional name: 2,4,6-trimethylbenzenesulfonyl chloride
• Synonyms: 2,4,6-Trimethylbenzenesulfonyl chloride

DATABASE IDS

• EC Number: 212-257-8
• Beilstein Number: 1107601
• CAS Number: 773-64-8
• MDL Number: MFCD00007434

PROPERTIES

• Purity: 99%
• Boiling Point: 150°C/20mm
• Flash Point: >110°C(230°F)
• Melting Point: 53-57°C
• GHS Hazard statements: H314-H318
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• Risk Statements: 34
• RTECS: DB8930000
• Safety Statements: 26-36/37/39-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否
• Hazard Class: 8
• UN Number: UN3096
• Packing Group: II

REFERENCES

• For reviews of the use of hindered sulfonyl chlorides as condensing agents for the formation of the phosphate link of oligonucleotides, see: Angew. Chem. Int. Ed., 11, 451 (1972); Synthesis, 222 (1975); Chem. Rev., 77, 183 (1977). For reviews of oligonucleotide synthesis by the phosphotriester method, see: Heterocycles, 7, 1197 (1977); Tetrahedron, 34, 3143 (1978). Compare 2,4,6-Triisopropylbenzenesulfonyl chloride, A11458.
• Reagent for protection of the guanidino function of arginine residues as mesitylenesulfonyl (Mts) derivatives in peptide synthesis: J. Chem. Soc., Chem. Commun., 482 (1978); Chem. Pharm. Bull., 26, 3752 (1978); Int. J. Pept. Prot. Res., 14, 169 (1979). Deprotection can be effected with triflic acid in TFA in the presence of thioanisole as a cation scavenger: J. Chem. Soc., Chem. Commun., 1063 (1980).
• The indole nitrogen, e.g. in tryptophan residues, may also be protected as the Mts amide, stable to dilute alkali, hydrazine hydrate, TFA, 4N HCl in dioxane, or HBr in AcOH, but cleaved by MsOH, or TfOH in TFA: Chem. Pharm. Bull., 32, 2660 (1984). See Appendix 6.
• Selective reagent for sulfonylation of carbohydrates: J. Chem. Soc., Perkin 1, 1373 (1974).