Methyl phenyl sulfone

• Catalog No.: A11727
• CAS Number: 3112-85-4
• M. F.: C7H8O2S
• M. W.: 156.20222
• Purity: 98+%

SYNONYMS

• Title: 甲基苯基砜
• IUPAC name: methanesulfonylbenzene
• IUPAC Traditional name: sulfone, phenyl, methyl-

DATABASE IDS

• MDL Number: MFCD00014741
• Beilstein Number: 1906914
• EC Number: 221-476-8
• CAS Number: 3112-85-4

PROPERTIES

• Purity: 98+%
• Melting Point: 85-88°C
• GHS Hazard statements: H302
• European Hazard Symbols: X
• GHS Precautionary statements: P264-P270-P301+P312-P330-P501A
• Risk Statements: 22
• RTECS: WR6800000
• Safety Statements: 36
• TSCA Listed: 否

REFERENCES

• Factors governing the selective alkylation have been studied. Lithium bases favor dialkylation. For monoalkylation, a potassium base, e.g. KH in THF, should be used: J. Org. Chem., 55, 2234 (1990).
• Adds to aldehydes and ketones in the presence of base, e.g. n-BuLi, to give ?-hydroxy sulfones. Conversion of the OH to, e.g. to mesylate, and elimination/desulfurative reduction with sodium amalgam provides a 1-substitued or 1,1-disubstituted alkene by the Julia olefination reaction: Tetrahedron Lett., 4833 (1973); J. Chem. Soc., Perkin 1, 829 (1978). For reaction scheme, see Ethyl phenyl sulfone, A10710. The adducts with aldehydes can also be rearranged to give the dimethyl acetals of the homologous aldehydes: J. Chem. Soc., Perkin 1, 1646 (1978). Reaction with acyl halides gives ?-keto sulfones: J. Org. Chem., 53, 906 (1988).