2,5-Dimethoxytetrahydrofuran, cis + trans

• Catalog No.: A11687
• CAS Number: 696-59-3
• M. F.: C6H12O3
• M. W.: 132.15768
• Purity: 98%

SYNONYMS

• Title: 2,5-二甲氧基四氢呋喃, 顺 + 反
• IUPAC name: 2,5-dimethoxyoxolane
• IUPAC Traditional name: 2,5-dimethoxyoxolane

DATABASE IDS

• EC Number: 211-797-1
• MDL Number: MFCD00005359
• CAS Number: 696-59-3
• Beilstein Number: 104261

PROPERTIES

• Purity: 98%
• Boiling Point: 145-147°C
• Density: 1.020
• Flash Point: 35°C(95°F)
• Melting Point: -45°C
• Refractive Index: 1.4180
• GHS Hazard statements: H330-H302-H315-H319-H335-H226
• European Hazard Symbols: X
• GHS Precautionary statements: P210-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501A
• Risk Statements: 10-20-36/37/38
• Safety Statements: 7-26-33-37-43
• Storage Warning: Air & Light Sensitive
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN3271
• Packing Group: III

REFERENCES

• Cyclic acetal and in situ source of succindialdehyde.
• Reacts with primary amines in boiling acetic acid to give N-substituted pyrroles: Acta Chem. Scand., 6, 667, 867 (1952); J. Heterocycl. Chem., 27, 1805 (1990); Org. Synth. Coll., 5, 716 (1973). Conversion to 1,4-dichloro-1,4-dimethoxybutane with TMS chloride allows cyclization with Amberlyst. A-21 resin, avoiding acidic conditions: J. Org. Chem., 48, 3059 (1983). Chiral 1-substituted pyrrole derivatives have been prepared using amino acids: Tetrahedron: Asymmetry, 7, 1069 (1996):
  
• N-substituted pyrroles have also been formed with sulfonamides and primary amides. P₂O₅ has been reported to give superior results in this type of reaction: Synth. Commun., 25, 1857 (1995).