1-Bromo-4-fluorobenzene

• Catalog No.: A11630
• CAS Number: 460-00-4
• M. F.: C6H4BrF
• M. W.: 174.9983632
• Purity: 99%

SYNONYMS

• Title: 1-溴-4-氟苯
• IUPAC name: 1-bromo-4-fluorobenzene
• IUPAC Traditional name: P-bromofluorobenzene
• Synonyms: 4-Bromofluorobenzene

DATABASE IDS

• MDL Number: MFCD00000342
• EC Number: 207-300-2
• CAS Number: 460-00-4
• Beilstein Number: 774102

PROPERTIES

• Purity: 99%
• Boiling Point: 151-153°C
• Density: 1.604
• Flash Point: 60°C(140°F)
• Melting Point: -16°C
• Refractive Index: 1.5270
• GHS Hazard statements: H226-H332-H319-H313
• European Hazard Symbols: X
• GHS Precautionary statements: P261-P305+P351+P338
• Risk Statements: 10-20-36
• RTECS: CY9033750
• Safety Statements: 26
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN1993
• Packing Group: III

REFERENCES

• The Br undergoes selective displacement with Na alkoxides in NMP, in the presence of CuBr: Tetrahedron, 48, 3633 (1992).
• Lithiation with LDA at -75^o results mainly in deprotonation ortho to F; subsequent reaction with CO₂ gives 5-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 33, 7495 (1992). Improved yields are obtained by the use of Li 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).