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2,2,2-Trifluoroacetophenone_Molecular_structure_CAS_434-45-7)
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2,2,2-Trifluoroacetophenone

Catalog No. A11403 Name Alfa Aesar
CAS Number 434-45-7 Website
M. F. C8H5F3O Telephone
M. W. 174.1199096 Fax
Purity 98% Email
Storage Chembase ID: 8127

SYNONYMS

Title
2,2,2-三氟苯乙酮
IUPAC name
2,2,2-trifluoro-1-phenylethan-1-one
IUPAC Traditional name
trifluoroacetophenone
Synonyms
Trifluoroacetylbenzene
Phenyl trifluoromethyl ketone

DATABASE IDS

EC Number 207-103-1
MDL Number MFCD00000420
CAS Number 434-45-7
Beilstein Number 1866286

PROPERTIES

Purity 98%
Boiling Point 165-166°C
Density 1.240
Flash Point 42°C(108°F)
Melting Point -40°C
Refractive Index 1.4595
GHS Pictograms GHS02
GHS Pictograms GHS07
GHS Hazard statements H226-H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
GHS Precautionary statements P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
Risk Statements 10-36/37/38
Safety Statements 26-37
TSCA Listed
Hazard Class 3
UN Number UN1224
Packing Group III

DETAILS

REFERENCES

  • Olefination with methanesulfonyl chloride, promoted by KF in DMF, gives ɑ -(trifluoromethyl)styrene in 92% yield: J. Org. Chem., 59, 2898 (1994).
  • Trifluoromethyl ketones undergo selective C-F bond cleavage with Mg in the presence of TMSCl, providing a convenient synthesis of 2,2-difluoro enol silanes: Chem. Commun., 1323 (1999).
  • Reaction with Dimethyl acetylenedicarboxylate, A11437, in the presence of triphenylphosphine, gives a highly-functionalized -butyrolactone: J. Org. Chem., 61, 4516 (1996):
  • In the presence of potassium monopersulfate (Oxone ), catalyzes the epoxidation of allylic alcohols via the in situ formed dioxirane: Tetrahedron, 56, 989 (1999).
  • In the presence of KO-t-Bu, acts as a nucleophilic trifluoromethylating agent, converting carbonyl compounds to trifluoromethyl alcohols: Tetrahedron Lett., 44, 1055 (2003).