2,2,2-Trifluoroacetophenone

• Catalog No.: A11403
• CAS Number: 434-45-7
• M. F.: C8H5F3O
• M. W.: 174.1199096
• Purity: 98%

SYNONYMS

• Title: 2,2,2-三氟苯乙酮
• IUPAC name: 2,2,2-trifluoro-1-phenylethan-1-one
• IUPAC Traditional name: trifluoroacetophenone
• Synonyms: Trifluoroacetylbenzene; Phenyl trifluoromethyl ketone

DATABASE IDS

• EC Number: 207-103-1
• MDL Number: MFCD00000420
• CAS Number: 434-45-7
• Beilstein Number: 1866286

PROPERTIES

• Purity: 98%
• Boiling Point: 165-166°C
• Density: 1.240
• Flash Point: 42°C(108°F)
• Melting Point: -40°C
• Refractive Index: 1.4595
• GHS Hazard statements: H226-H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 10-36/37/38
• Safety Statements: 26-37
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN1224
• Packing Group: III

REFERENCES

• Olefination with methanesulfonyl chloride, promoted by KF in DMF, gives ɑ -(trifluoromethyl)styrene in 92% yield: J. Org. Chem., 59, 2898 (1994).
• Trifluoromethyl ketones undergo selective C-F bond cleavage with Mg in the presence of TMSCl, providing a convenient synthesis of 2,2-difluoro enol silanes: Chem. Commun., 1323 (1999).
• Reaction with Dimethyl acetylenedicarboxylate, A11437, in the presence of triphenylphosphine, gives a highly-functionalized -butyrolactone: J. Org. Chem., 61, 4516 (1996):
  
• In the presence of potassium monopersulfate (Oxone ), catalyzes the epoxidation of allylic alcohols via the in situ formed dioxirane: Tetrahedron, 56, 989 (1999).
• In the presence of KO-t-Bu, acts as a nucleophilic trifluoromethylating agent, converting carbonyl compounds to trifluoromethyl alcohols: Tetrahedron Lett., 44, 1055 (2003).