2,4,6-Collidine

• Catalog No.: A11058
• CAS Number: 108-75-8
• M. F.: C8H11N
• M. W.: 121.17964
• Purity: 99%

SYNONYMS

• Title: 2,4,6-三甲基吡啶
• IUPAC name: 2,4,6-trimethylpyridine
• IUPAC Traditional name: 2,4,6-collidine
• Synonyms: 2,4,6-Trimethylpyridine

DATABASE IDS

• EC Number: 203-613-3
• Merck Index: 149718
• MDL Number: MFCD00006338
• Beilstein Number: 107283
• CAS Number: 108-75-8

PROPERTIES

• Purity: 99%
• Boiling Point: 171-172°C
• Density: 0.916
• Flash Point: 54°C(129°F)
• Melting Point: -43°C
• Refractive Index: 1.4980
• GHS Hazard statements: H226-H302-H312-H315-H319-H335
• European Hazard Symbols: X
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 10-21/22-36/37/38
• RTECS: UU0970000
• Safety Statements: 26-36/37
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN1992
• Packing Group: III

REFERENCES

• Hindered base. For use in the dehydrochlorination of ɑ-chloroketones to enones, see: Org. Synth. Coll., 4, 162 (1963). For use in combination with Trifluoromethanesulfonic anhydride, A11767 for the generation of ketenimines from olefins, see N,N-Dimethylacetamide, A10924.
• Superior base for peptide coupling reactions, causing less racemization than the more commonly used N-ethyldiisopropylamine or N-methylmorpholine: J. Org. Chem., 59,695 (1994). For comparison with other hindered bases, see: J. Org. Chem., 61, 2460 (1996). For peptide reagents, see Appendix 6.
• Solvent for various O-alkyl cleavage reaction by LiI, including hindered esters: J. Org. Chem., 28, 2184 (1963), and methyl ethers of phenols: Chem. Commun., 616 (1969).