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2-(Phenylthio)ethanol

Catalog No. A10861 Name Alfa Aesar
CAS Number 699-12-7 Website
M. F. C8H10OS Telephone
M. W. 154.2294 Fax
Purity 99% Email
Storage Chembase ID: 8013

SYNONYMS

Title
2-(苯硫基)乙醇
IUPAC name
2-(phenylsulfanyl)ethan-1-ol
IUPAC Traditional name
2-(phenylsulfanyl)ethanol
Synonyms
2-Hydroxyethyl phenyl sulfide

DATABASE IDS

Beilstein Number 1860057
MDL Number MFCD00002905
EC Number 211-828-9
CAS Number 699-12-7

PROPERTIES

Purity 99%
Boiling Point 115-116°C/2mm
Density 1.147
Flash Point >110°C(230°F)
Refractive Index 1.5905
Safety Statements 24/25
TSCA Listed

DETAILS

REFERENCES

  • Reagent for phosphate protection in oligonucleotide synthesis. The resulting esters are stable to base, sulfonylation, and to mild acid, but can be deprotected by periodate oxidation to the sulfoxide: Can. J. Chem., 50, 456, 769 (1972), or NCS oxidation to the sulfone: J. Am. Chem. Soc., 95, 2020 (1973), either of which can then be cleaved by base-induced elimination. For use in pyrimidine protection of thymidine analogs, via Mitsunobu N-alkylation, m-CPBA oxidation to the sulfone and cleavage with dilute NaOH, see: Synlett, 845 (2006).